The recently published National Military Strategy emphasizes the unpredictability of the global security environment. According to General Dempsey, “global disorder has significantly increased while some of our comparative military advantage has begun to erode. We now face multiple, simultaneous security challenges…” General Odierno echoes this concern by pointing to the “increased velocity of instability,” and emboldened potential adversaries that have “magnified the risk to U.S. interests around the world.” Responding to this period of geopolitical uncertainty demands thoughtful and careful analysis of a wide array of strategic issues. The Strategic Studies Institutes’ (SSI) annual Key Strategic Issues List (KSIL) addresses this need by providing a list of high-priority topics organized to support the Army's most important strategic objectives, issues that must be addressed to ensure the Army of 2025 and beyond will continue to meet the needs of the nation. Part I of the KSIL lists the Chief of Staff of the Army’s top five topics, all five of which will be addressed as integrative research projects by the US Army War College. Part II, “Priority Research Areas,” is a compilation of critical topics developed by the Army War College and Commands and organizations throughout the Army. Part III consists of the Army Warfighting Challenges. Students and researchers are encouraged to get in touch with the topic sponsors listed in the document, tackle one of these issues, and contribute to the knowledge base needed to support the future direction of the Army.