The 21st century is the “connected century.” Globalization has created social and economic interconnectedness more broadly and deeply than at any other time in history. At the same time, America has entered this century without a grand strategy around which it will shape the environment to suit its interests. This paper will examine the concept of grand strategy and the lack thereof that led to failed nation-building efforts that bookend the post-Cold War period. It will then describe the current global environment and the constraints and restraints that will impact any American grand strategy for the remainder of the 21st century. Finally, the paper will proffer partnerships with India and Indonesia as two mechanisms for increasing global connectivity by cementing the position of those two nations within the global functioning core.